Epitalon Store

The literature

Epitalon references: the cited record

Every study cited on this site, with DOIs and PubMed links, sortable by year and model.

Read the researchBack to the overview

About these Epitalon references

These are the Epitalon references cited across this site, listed in full with DOIs and PubMed identifiers. The list is deliberately transparent about evidence tier: it spans in-vitro human-cell work, rodent lifespan and carcinogenesis studies, a rat pinealocyte melatonin study, observational human cohorts using the parent extract, and two 2025 papers that mark the beginning of independent Western engagement with the telomere claim. Where a study used the parent extract epithalamin rather than synthetic Epitalon, or was observational rather than randomized, that is reflected in how it is described on the research and effects pages. Each entry below corresponds to the bracketed [N] citation markers used throughout the site.

  1. Khavinson VK, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592. ↗
  2. Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003;24(3-4):233-240. ↗
  3. Anisimov VN, Khavinson VKh, Provinciali M, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202. ↗
  4. Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł. Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025;26(6):2691. ↗
  5. Al-Dulaimi S, Thomas R, Matta S, Roberts T. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025;26(5):178. ↗
  6. Khavinson VKh, Linkova NS, Kvetnoy IM, et al. Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture. Bull Exp Biol Med. 2012;153(2):255-258. ↗
  7. Anisimov VN, Khavinson VKh, Provinciali M, et al. Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic HER-2/neu mice. Bull Exp Biol Med. 2002;133(2):139-143. ↗
  8. Kossoy G, Anisimov VN, Ben-Hur H, et al. Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. Cancer Lett. 2002;183(1):1-4. ↗
  9. Anisimov VN, Khavinson VKh, Provinciali M, et al. Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Int J Cancer. 2002;101(1):7-10. ↗
  10. Anisimov VN, Khavinson VKh, et al. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo. 2006;20(2):281-284. ↗
  11. Anisimov VN, Khavinson VKh, et al. Effect of Epitalon and Vilon treatment on mammary carcinogenesis in transgenic erbB-2/NEU mice. Vopr Onkol. 2002;48(1):33-37. ↗
  12. Korkushko OV, Shatilo VB, Khavinson VKh, et al. Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging. Bull Exp Biol Med. 2006;142(1):73-77. ↗
  13. Khavinson VKh, et al. Identification of Peptide AEDG in the Polypeptide Complex of the Pineal Gland. Bull Exp Biol Med. 2017;164(1):41-43. ↗
  14. Effects of intranasal administration of epitalon on neuron activity in the rat neocortex. Neurosci Behav Physiol. 2007;37(7):673-677. ↗
  15. Anisimov VN, Khavinson VKh, Morozov VG. Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats. Mech Ageing Dev. 1998;103(2):123-132. ↗